THE BINDER LAB

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MASCHA BINDER

Director / lab head

Mascha heads the Hematology/Oncology department at the University Medical Center in Halle (Saale) since 2018. Before, she studied medicine in Würzburg, Freiburg and Rome and worked as an oncologist at the University of Freiburg and Hamburg-Eppendorf. Clinically, she focuses on solid tumor immunotherapy and the treatment of lymphoid cancers. In her research, she strives for a better understanding of the mechanisms underlying resistance to develop next-generation targeting options.

Mascha is a big fan of immune repertoires, liquid biopsies and CAR-T cells.

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LISA PASCHOLD

Postdoc

Lisa received her PhD in Biochemistry at the Leipzig University. She joined the Binder lab in 2019 as a wet lab scientist but her days have gotten increasingly dry. She especially enjoys deep diving into NGS data sets covering immunosequencing and somatic mutations. She is working on B and T cell receptor landscapes in hematological malignancies and infectious diseases. Accompanying clinical trials, often in the setting of immune checkpoint blockade in solid cancers, Lisa explores liquid biopsies to characterize both immune responses as well as tumor progress during therapy. Outside the lab you will find her by the seaside or hanging off a wall.

Postdoc

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CHRISTOPH SCHULTHEISS

Christoph received his PhD in molecular genetics at the Johannes Gutenberg-University Mainz. After a detour to biotech industry he joined Mascha´s lab in Hamburg in 2018. He works on immuno-genetic questions related to autoimmunity, cancer and infection. In addition, he tries to better understand B cell receptor signaling and how therapeutic resistance works on the molecular level. It has become his lifetime task to convince R people that the terminal is not as beautiful as western blots. If he is not in the lab you can reliably find him at any nearby concert with at least one guitar on the stage.

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EDITH WILLSCHER

Bioinformatician

Edith is a bioinformatician and mainly works in the field of computational immunology. She has longstanding experience in global gene expression analyses and supports the group with new programmed tools, R knowledge and by implementing new published methods. In her freetime, she likes hiking and watching good movies.

Clinician scientist

Luise studied medicine in Tübingen and Leipzig, with research visits in Copenhagen and London. During her doctoral thesis in the field of computational psychiatry she discovered the beauty of finding structure in large datasets. In 2021 she joined the Department of Hematology/Oncology at the University Medical Center in Halle (Saale). Since then, the term “from bench to bedside” has gained new significance for her. While carrying out clinical trials in the outpatient clinic, she also strives to find immunrepertoire characteristics and mutations in solid tumors predictive for treatment response. In her spare time, she reads feminist literature and adopts a lot of houseplants.

Tianjiao received her M.D. from Peking Union Medical College, Beijing, China. Currently she works as a doctor in the department of Internal Medicine IV, Oncology/Hematology, Martin Luther University Halle-Wittenberg, Halle, Germany. She is interested in targeted therapy in hematological malignancies and as physician scientist involved in a project of  CAR-T cell therapy in CLL.  

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LUISE CLAASS

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TIANJIAO ZHANG

Clinician scientist

Clinician Scientist

Juliane has joined our team from Leipzig with the clear aim to be a passionate doctor and a wholehearted scientist in the field of AML. In a truly translational "myeloid" project, she happened to find enthusiasm for the role of other hematopoietic lineages in the bone marrow niche. 

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JULIANE GRIMM

MURTAZA ALI

PhD student

Murtaza seeks for solutions to target endocrine neoplasms. He is most thrilled by CAR T cells and their selectivity for tumor tissue if extremely tissue-specific hormone receptors are used as targets.

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DENIS OWCZAREK

PhD student

ALINE PATSCHKE

Lab technician

Denis studied in Braunschweig with a research stay in Helsinki. During his studies he developed a fascination for antibodies and the beauty of their applications. In his master thesis he worked on establishing a novel diagnostic approach by coupling antibodies with magnetic nanoparticles. He then found joy working in the antibody discovery unit of a small start-up that produced antibodies animal free for the diagnostic market. He is now eager to translate all his accumulated experience from Phage-Display, Protein-Engineering and Protein-Protein-Interaction into the development of CARs against unique targets. When Denis is not in the lab, he is probably doing some kind of sport, from running to bouldering to cycling.

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Aline joined the lab in 2020 and has already become a serious specialist in immune repertoire sequencing, always ready to accept new challenges. Due to this attitude, she qualified for operating the holy MiSeq after no time. 

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CHRISTOPH WOSIEK

Lab technician

Christoph is our technical director mastering our complicated trial biobanks and always keeping track of the big picture. With his vanguard way of wearing the face mask, he always makes a good impression in these Corona times.

Lab technician

JENNY WEHDE

Jenny joined the immune repertoire sequencing branch of our team. Without her help, we wouldn't be able to manage the daily tsunami of trial liquid biopsies.

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KATRIN NERGER

Lab technician

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MORITZ ESCHER

Medical student

Katrin is working as medical technician since the starting years of the research lab of the Oncology in Halle (Saale). With a broad spectrum of methods like cell culture, cultivation of mesenchymal stem cells, western blot and PCR, flow cytometry, immunohistochemistry and many others she loves everything that has to be pipetted and incubated. In private she enjoys to see the vegetables, fruit and flowers grow after incubation with water and natural fertilizer in her little garden.

Moritz is studying human medicine at the Martin-Luther-University Halle-Wittenberg and is currently working on the interaction of B-cell receptor signaling and driver mutations in B-cell lymphoma. After completing his studies, he would like to specialize in the field of hematology. In his spare time, he enjoys playing the piano, doing video and photo editing, playing boardgames and tinkering with his homeserver and networking-related topics. Prior to medical school, Moritz worked as a physiotherapist near Dresden, Germany.

Hanna is a liquid biopsy professional in our group with special expertise in very very deep analyzes. The shallow NGS waters don't thrill her too much. Coming from head and neck cancer, she currently expands her field of activity to colorectal cancer. 

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HANNA JONAS

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NAMUUN CHINCHULUUN

Medical student

Namuun has done part of her bachelor and a Hiwi job in our lab but still can't get enough of tumor immunology, so that she now joins for her master.

HONORARY LAB MEMBERS

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ALEX STEIN

Study guru

Alex is one of our prime collaboration partners. He is a serious expert in trial design, trial conduct and acquisition of trial funding and an excellent oncologist we are proud to work with.

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MALTE MOHME

Dr Brain

Malte's favorite hobby are immune cells fighting brain tumors. He has extensive biobanks of all kinds of brain tumors and is after a better understanding of why - often enough - central nervous adaptive immune cells are unable to provide better tumor control.

Some of our most famous ALUMNI

Svenja Henkes

Master student

Svenja was a master student in the lab in 2021. She solved the translational part of the INTEGA trial which addresses the efficacy of immune checkpoint blockade and its optimal combination partners in HER2+ esophagogastric adenocarcinoma (EGA). She now has an inudstry position.

DONJETE SIMNICA

Postdoc

Dona joined the Binder lab in 2017 as PhD student and left in December 2021 after one year as postdoc. Dona´s input was critical to guide the Binder lab into a post-Excel era and form our research profile regarding immune repertoires and clinical studies.

She will soon start as postdoc in Sebastian Kobold´s group at the LMU Munich focusing on experimental immunooncology.

LISA VON WENSERSKI

PhD student

ALISSA BEHN

Intern

Alissa was a lab intern in 2021. During this time she effortlessly outcompeted the cloning efficiency of our postodocs.

Lisa performed her PhD thesis from 2017 to 2021. She did a great job showing that high expression levels of SLAMF1 and SLAMF7 withdraw Prohibitin-2 from the B cell receptor complex thus reducing its signaling. This mechanism may contribute to the favorable clinical course of CLL with high SLAMF expression. Lisa now works in a molecular diagnostics lab.

REBEKKA SCHOLZ

Master student

MARTA SIEDLECKI

Lab technician

Marta was a technician in the lab from 2019-2020. She unfortunately decided to leave academia.

Rebekka was a Bachelor and Master student until 2020. She performed key experiments to characterize PD-L1 escape variants that emerged after Avelumab treatment in colorectal cancer.

She now works at the German Center of Neurodegenerative Diseases (DZNE) in Bonn

JANINA SCHLÜTER

Lab wizard

Janina was a central lab member in Hamburg that managed everything from keeping up everybody's spirits to lab organization and eventually also PCR.

BARBARA GÖSCH

Lab technician

Barbara worked as a technician at the Hamburg lab with us. She had a wealth of experience in all kinds of techniques and moved our immune repertoire sequencing pipeline significantly forward.

ANITA SCHULENKORF

Lab technician

Anita was the good soul of our Hamburg lab. She new all techniques and contributed to the success of numerous bachelor, master and doctoral thesis by passing on her knowledge.

Joseph is a clinician scientist interested in solid tumor immunotherapy. At our Hamburg lab, he worked on resistance mechanisms of targeted EGFR therapies and how to overcome them with nanobodies.

He is now a physician at the Hematology/Oncology Departmant at the UKE and a member of Nicola Gagliani´s research group in Hamburg.

JOSEPH TINTELNOT

MD

SIMON SCHLIFFKE

MD

During his time at the Hematology/Oncology Department at the UKE in Hamburg, he was a passionate memer of the lab. His research addressed therapy and resistance of B cell lymphomas and immunophenotyping of CNS-inflitrating lymphocytes. He now works as an oncologist in Hamburg.

NURAY AKYÜZ

Postdoc

Nuray was the first generation of scientists in our lab, that found herself in the middle of our transition from excel (that she mastered in a way that not many people do!!) to R. She is a scientist at the Hematology/Oncology Department at the UKE.

ANNA OBERLE

Postdoc

Anna did her PhD and her first Post-Doc at the Hamburg lab - always curious to detect even minimal traces of myeloma-specific DNA rearrangements in blood. An austrian scientist from the next-door lab hijacked her, transfered her to Vienna and transformed her northern accent to some very funny german-austrian hybrid tongue.

BENJAMIN THIELE

MD

Benni qualified for "excellent student" mentoring after his first months as a medical student. Ever since, he is a close friend of the Binder Lab. He managed to publish in Blood during his MD thesis (falsifying a long-standing hypothesis on myeloma precursor cells) and contributed a lot of crazy ideas to our projects. 

NATALIE BAUM

PhD student

Nati began her PhD thesis at the Binder Lab and finished it in the Nolte Lab at the UKE. Despite the change of lab, she kept her original research question and the project on alternative ways of EGFR targeting became a trans-laboratory success!

FRIEDERIKE BRAIG

PhD student

Fritzi was the first PhD at the Binder Lab. She was a pioneer in everything she did and with her most unusual organizational skills, she created a famous system of highest work efficacy (the so-called Fritzi's Listen). She set the standard of >8 publications per PhD.